Case report: Castleman disease in association with POEMS.

Abstract

Castleman disease, or angiofollicular lymph node hyperplasia, and POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, and Skin changes), are associated and can lead to a clinical conundrum. The physician caring for a patient with Castleman disease should be alert to the development of multiple endocrine deficiencies, including primary hypogonadism, diabetes mellitus, hypothyroidism, and adrenal insufficiency. Avoidance of treating hypothyroidism alone when there is concomitant subclinical adrenal insufficiency is important, to avoid precipitating an adrenal crisis. A better outcome may result from earlier recognition of the endocrinopathies of this syndrome. This article describes a patient with Castleman disease in whom the features of POEMS unfolded over the ensuing years.

• Authors: H M Adelman, M L Cacciatore, J F Pascual, J M Mike, W M Alberts, P M Wallach
• Journal: The American journal of the medical sciences (Am J Med Sci) Vol. 307 Issue 2 Pg. 112-4 (Feb 1994) ISSN: 0002-9629 [Print] United States
• PMID: 8141136 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Adrenocorticotropic Hormone
• Thyrotropin
• Thyroxine
• Hydrocortisone

Topics

• Adrenal Cortex Hormones
• Adrenocorticotropic Hormone
• Castleman Disease (complications, diagnosis, diagnostic imaging)
• Follow-Up Studies
• Humans
• Hydrocortisone (blood)
• Hypothyroidism (diagnosis, drug therapy)
• Male
• Middle Aged
• POEMS Syndrome (complications, diagnosis)
• Thyroid Function Tests
• Thyrotropin (blood)
• Thyroxine (therapeutic use)
• Tomography, X-Ray Computed