Probable acenocoumarol-amoxycillin interaction.

Abstract

We present the case of a woman undergoing treatment with acenocoumarol for deep vein thrombosis, who maintained an international normalized ratio (INR) of between 2.5 and 4 for 2 months. Seven days after the introduction of amoxycillin (500 mg/8 h) for a probable respiratory infection, the patient developed spontaneous bruising, with an INR of 7.1. Treatment with amoxycillin was discontinued, and 3 weeks later the INR had returned to previous values. In this case, the increase in the INR value with associated bruising after the addition of amoxycillin suggests a drug interaction between acenocoumarol and amoxycillin, other possible causes having been eliminated.

• Authors: J Soto, J A Sacristan, M J Alsar, C Fernandez-Viadero, R Verduga
• Journal: Acta haematologica (Acta Haematol) Vol. 90 Issue 4 Pg. 195-7 ( 1993) ISSN: 0001-5792 [Print] Switzerland
• PMID: 8140860 (Publication Type: Case Reports, Journal Article)

Chemical References

• Amoxicillin
• Acenocoumarol

Topics

• Acenocoumarol (administration & dosage, adverse effects)
• Aged
• Aged, 80 and over
• Amoxicillin (adverse effects)
• Drug Interactions
• Drug Therapy, Combination
• Female
• Humans
• Postoperative Complications (blood, drug therapy)
• Respiratory Tract Infections (blood, drug therapy)
• Thrombophlebitis (blood, drug therapy)
• Time Factors