Disease recurrence after orthotopic liver transplantation.

Abstract

With the advent of cyclosporine immunosuppression in the late 1970s, liver transplantation became a widespread modality for the treatment of end-stage liver disease. Several metabolic disorders that produce liver injury, such as Wilson's disease and alpha-1-antitrypsin deficiency, are cured by liver transplantation. However, many other diseases for which transplantation is undertaken may recur in the allograft. As follow-up increases and newer diagnostic modalities become available, those diseases that recur, and their natural histories, are becoming better understood. This new information may lead to a reevaluation of the suitability of some conditions for transplantation. This article briefly reviews disease recurrence in orthotopic liver transplants.

• Authors: O W Cummings
• Journal: Seminars in diagnostic pathology (Semin Diagn Pathol) Vol. 10 Issue 4 Pg. 292-301 (Nov 1993) ISSN: 0740-2570 [Print] United States
• PMID: 8140327 (Publication Type: Journal Article, Review)

Topics

• Biliary Tract Diseases (pathology)
• Hepatitis, Viral, Human (pathology)
• Humans
• Liver Diseases (pathology, surgery)
• Liver Neoplasms (pathology)
• Liver Transplantation (pathology)
• Recurrence