[Therapy of simple endometrial hyperplasia with GnRH analogs. Evaluation of a multicentric ambulatory study. Preliminary results].

Abstract

Endometrial hyperplasia is a frequent pathology during menopause and involves the risk of malignant transformation of the lesions. In an attempt to avoid radical surgery, this study proposes the use of triptorelin which was used to treat 56 patients with histologically confirmed symptoms of endometrial hyperplasia without atypia. GnRH-analog was administered using the intramuscular route every 28 days for 6 months. Histological controls were carried out 30 days after the last injection and showed the resolution of histological symptoms, confirmed after three months.

• Authors: R Zagni, R Cortelazzi, L Cipolla, G Giannetta, B Ferrante, A Soliani
• Journal: Minerva ginecologica (Minerva Ginecol) Vol. 45 Issue 12 Pg. 597-602 (Dec 1993) ISSN: 0026-4784 [Print] Italy
• Vernacular Title: Trattamento con GnRH analoghi della iperplasia endometriale semplice. Valutazione di uno studio policentrico ambulatoriale. Risultati preliminari.
• PMID: 8139785 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Triptorelin Pamoate
• Gonadotropin-Releasing Hormone

Topics

• Adult
• Ambulatory Care
• Endometrial Hyperplasia (therapy)
• Female
• Gonadotropin-Releasing Hormone (administration & dosage)
• Humans
• Middle Aged
• Triptorelin Pamoate (administration & dosage)