Abstract | PURPOSE: The aim of this study was to describe the natural history and management of surgically unresectable intra-abdominal desmoid tumors in two patients with Gardner's syndrome from two unrelated families, where each had failed on conventional therapy. METHODS: RESULTS: The computerized abdominal tomography scans proved difficult to interpret because of adhesions and matted small bowel resulting from the patients original colectomies. These findings made it difficult to differentiate postoperative changes from residual desmoid tumor. Second-look laparotomy in such patients was contraindicated as this may predispose to further desmoid production. Laparoscopy disclosed a complete response to this chemotherapy. Nevertheless, we had an iatrogenic small bowel perforation in one of these patients. Each patient showed a complete response to chemotherapy. CONCLUSION:
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Authors | H T Lynch, R Fitzgibbons Jr, S Chong, J Cavalieri, J Lynch, F Wallace, S Patel |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 37
Issue 3
Pg. 260-7
(Mar 1994)
ISSN: 0012-3706 [Print] United States |
PMID | 8137673
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
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Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Dacarbazine
(administration & dosage)
- Doxorubicin
(administration & dosage)
- Female
- Fibromatosis, Abdominal
(complications, diagnosis, drug therapy)
- Gardner Syndrome
(complications, genetics)
- Humans
- Laparoscopy
- Male
- Pedigree
- Tomography, X-Ray Computed
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