Abstract |
Sneddon's syndrome, cerebrovascular thrombosis and livedo reticularis, is often a variant of the "primary" anti-phospholipid syndrome (PAPS). We report a woman with PAPS, presenting as Sneddon's syndrome, with renal impairment and glomerular thrombosis on renal biopsy. An IgG anti- cardiolipin antibody (aCL) was identified. The aCL was purified by affinity chromatography, gel filtration chromatography and ion-exchange chromatography, assayed in a modified ELISA and found to be of the type that requires the plasma protein beta 2-GPI to bind aCL. As beta 2-GPI has anticoagulant properties it is postulated that its interaction with aCL has a pathogenic role in the thrombotic lesions associated with aCL.
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Authors | J M Stevens, J E Hunt, A E Seymour, S A Krilis, D J Pugsley |
Journal | Clinical nephrology
(Clin Nephrol)
Vol. 41
Issue 1
Pg. 18-22
(Jan 1994)
ISSN: 0301-0430 [Print] Germany |
PMID | 8137565
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies, Anticardiolipin
- Immunoglobulin G
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Topics |
- Adult
- Antibodies, Anticardiolipin
(analysis)
- Antiphospholipid Syndrome
(complications, immunology, pathology)
- Female
- Humans
- Immunoglobulin G
(analysis)
- Intracranial Embolism and Thrombosis
(etiology, immunology, pathology)
- Kidney Diseases
(etiology)
- Kidney Glomerulus
- Pigmentation Disorders
(etiology)
- Skin Diseases, Vascular
(etiology, immunology, pathology)
- Syndrome
- Thrombosis
(etiology)
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