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Antitumoral cyclic peptide analogues of chlamydocin.

Abstract
A series of cyclic tetrapeptides bearing the bioactive alkylating group on an epsilon-amino-lysyl function have been examined for their antitumoral activity on L1210 and P388 murine leukemia cell lines. One analogue belonging to the chlamydocin family and bearing a beta-chloroethylnitrosourea group was found to be potent at inhibiting L1210 cell proliferation and had a higher therapeutic index than the reference compound bis-beta-chloroethylnitrosourea (BCNU) on the in vivo P388-induced leukemia model.
AuthorsE Bernardi, J L Fauchere, G Atassi, P Viallefont, R Lazaro
JournalPeptides (Peptides) 1993 Nov-Dec Vol. 14 Issue 6 Pg. 1091-3 ISSN: 0196-9781 [Print] United States
PMID8134289 (Publication Type: Journal Article)
Chemical References
  • Antibiotics, Antineoplastic
  • Peptides, Cyclic
  • chlamydocin
  • Lysine
Topics
  • Amino Acid Sequence
  • Animals
  • Antibiotics, Antineoplastic (chemical synthesis, pharmacology)
  • Drug Screening Assays, Antitumor
  • Female
  • Leukemia L1210 (drug therapy)
  • Leukemia P388 (drug therapy)
  • Lysine
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Molecular Sequence Data
  • Peptides, Cyclic (chemical synthesis, pharmacology)

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