Abstract |
A series of cyclic tetrapeptides bearing the bioactive alkylating group on an epsilon-amino-lysyl function have been examined for their antitumoral activity on L1210 and P388 murine leukemia cell lines. One analogue belonging to the chlamydocin family and bearing a beta-chloroethylnitrosourea group was found to be potent at inhibiting L1210 cell proliferation and had a higher therapeutic index than the reference compound bis-beta-chloroethylnitrosourea ( BCNU) on the in vivo P388-induced leukemia model.
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Authors | E Bernardi, J L Fauchere, G Atassi, P Viallefont, R Lazaro |
Journal | Peptides
(Peptides)
1993 Nov-Dec
Vol. 14
Issue 6
Pg. 1091-3
ISSN: 0196-9781 [Print] United States |
PMID | 8134289
(Publication Type: Journal Article)
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Chemical References |
- Antibiotics, Antineoplastic
- Peptides, Cyclic
- chlamydocin
- Lysine
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Topics |
- Amino Acid Sequence
- Animals
- Antibiotics, Antineoplastic
(chemical synthesis, pharmacology)
- Drug Screening Assays, Antitumor
- Female
- Leukemia L1210
(drug therapy)
- Leukemia P388
(drug therapy)
- Lysine
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Molecular Sequence Data
- Peptides, Cyclic
(chemical synthesis, pharmacology)
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