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Inhibition of immediate hypersensitivity reactions in the rat by disodium cromoglycate and nitroindanedione.

AbstractA nitroindanedione (BRL 10833) and disodium cromoglycate (DSCG) showed similar activities as inhibitors of IgE-mediated passive cutaneous anaphylaxis (PCA) and passive peritoneal anaphylaxis (PPA) reactions in the rat. BRL 10833 was more active than DSCG when given parenterally and unlike DSCG it inhibited the PCA reaction in the rat after oral administration. In the PCA test both compounds produced a state of refractoriness both to themselves and to each other. Isoprenaline also inhibited the PCA reaction but its activity was not reduced when the rats were refractory to DSCG.
AuthorsB A Spicer, J W Ross, H Smith
JournalClinical and experimental immunology (Clin Exp Immunol) Vol. 21 Issue 3 Pg. 419-29 (Sep 1975) ISSN: 0009-9104 [Print] ENGLAND
PMID812623 (Publication Type: Journal Article)
Chemical References
  • SRS-A
  • Cromolyn Sodium
  • Histamine
Topics
  • Anaphylaxis
  • Animals
  • Cromolyn Sodium (administration & dosage, pharmacology)
  • Histamine (analysis)
  • Hypersensitivity, Immediate
  • Immunosuppression
  • Male
  • Passive Cutaneous Anaphylaxis (drug effects)
  • Rats
  • SRS-A (analysis)

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