Abstract | OBJECTIVE: CASE SUMMARY: Two patients treated with phenacemide were investigated for markedly increased Scr and decreased creatinine clearance (Clcr) values. Glomerular filtration rates, as determined by 125I-iothalamate clearance, were normal in both patients and analytical interferences with the Jaffé reaction were excluded. After discontinuation of the drug, phenacemide concentrations became undetectable within 2 days but it took 7-14 days for Scr and Clcr to return to normal values. DISCUSSION: CONCLUSIONS: Increased Scr concentrations in these patients could be related to an inhibition of transport and a decrease in creatinine volume of distribution. Creatinine concentrations should not be considered when dosage adjustments of renally eliminated drugs are being calculated for patients with such metabolic interferences.
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Authors | R Cahen, A Martin, B Francois, P Baltassat, P Louisot |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 28
Issue 1
Pg. 49-51
(Jan 1994)
ISSN: 1060-0280 [Print] United States |
PMID | 8123960
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anticonvulsants
- Benzeneacetamides
- Carbamazepine
- Urea
- Creatinine
- phenacemide
- Phenobarbital
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Topics |
- Adult
- Anticonvulsants
(adverse effects)
- Benzeneacetamides
- Carbamazepine
(therapeutic use)
- Creatinine
(blood)
- Epilepsy, Temporal Lobe
(blood, drug therapy)
- Glomerular Filtration Rate
- Humans
- Male
- Phenobarbital
(therapeutic use)
- Urea
(adverse effects, analogs & derivatives)
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