Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases.

Abstract

We have previously demonstrated that an antibody to phosphoinositide-specific phospholipase C (PLC) isozyme, PLC-delta, intensely stained neurofibrillary tangles (NFT) in the brain tissue of Alzheimer's disease (AD). This study was performed to determine if abnormal PLC-delta accumulation might be present in the filamentous inclusions of other neurodegenerative diseases. We found that the anti-PLC-delta antibody stained neuronal inclusions of Pick's disease, progressive supranuclear palsy and diffuse Lewy body disease while the inclusions of idiopathic Parkinson's disease lacked PLC-delta accumulation. These results suggest a possible role for PLC-delta interaction in the formation of intraneuronal filamentous inclusions in human neurodegenerative diseases.

• Authors: S Shimohama, G Perry, P Richey, T Takenawa, P J Whitehouse, K Miyoshi, T Suenaga, S Matsumoto, M Nishimura, J Kimura
• Journal: Neuroscience letters (Neurosci Lett) Vol. 162 Issue 1-2 Pg. 183-6 (Nov 12 1993) ISSN: 0304-3940 [Print] Ireland
• PMID: 8121625 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Type C Phospholipases

Topics

• Aged
• Aged, 80 and over
• Cerebral Cortex (enzymology, pathology)
• Dementia (enzymology, pathology)
• Hippocampus (enzymology, pathology)
• Humans
• Immunohistochemistry
• Inclusion Bodies (enzymology)
• Middle Aged
• Nervous System Diseases (enzymology, pathology)
• Neurofibrillary Tangles (enzymology, pathology)
• Parkinson Disease (enzymology, pathology)
• Supranuclear Palsy, Progressive (enzymology, pathology)
• Type C Phospholipases (metabolism)