The tachykinin NK1 receptor antagonist CP-99,994 attenuates cisplatin induced emesis in the ferret.

Abstract

The tachykinin NK1 receptor antagonist CP-99,994 ((+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine) (0.3-3 mg/kg i.v.), but not its inactive enantiomer CP-100,263, attenuated the retching and vomiting induced by cisplatin (10 mg/kg i.v.) in the ferret. CP-99,994, 3 mg/kg i.v., prevented vomiting in all ferrets tested. Since substance P is the preferred ligand at the NK1 receptor subtype these data support a role for the release of this peptide during the emetic response induced by cytotoxic chemotherapeutic agents.

• Authors: F D Tattersall, W Rycroft, R J Hargreaves, R G Hill
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 250 Issue 1 Pg. R5-6 (Nov 30 1993) ISSN: 0014-2999 [Print] Netherlands
• PMID: 8119305 (Publication Type: Journal Article)

Chemical References

• Piperidines
• 3-(2-methoxybenzylamino)-2-phenylpiperidine
• Neurokinin A
• Cisplatin

Topics

• Analysis of Variance
• Animals
• Cisplatin (toxicity)
• Ferrets
• Injections, Intravenous
• Male
• Neurokinin A (antagonists & inhibitors)
• Piperidines (administration & dosage, pharmacology)
• Vomiting (chemically induced, drug therapy)