Abstract |
The process of occurrence of bright blindness, progressive retinal degeneration (PRD), in sheep was observed using two Suffolk ram lambs fed on a diet containing bracken powder. The first sign of the bright blindness was detected 4 months after the start of experiment. Based on these preliminary results, the amount of bracken powder necessary to induce PRD was estimated (experiment I). In the following experiment, ptaquiloside (PT), a norsesquiterpene glucoside of the illudane type isolated from bracken, which is a bracken carcinogen and a causative principle of cattle bracken poisoning was administered to two Suffolk ram lambs. It was clearly demonstrated in this experiment (experiment II) that PT present in bracken is also a causative principle of PRD.
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Authors | I Hirono, M Ito, S Yagyu, M Haga, K Wakamatsu, T Kishikawa, O Nishikawa, K Yamada, M Ojika, H Kigoshi |
Journal | The Journal of veterinary medical science
(J Vet Med Sci)
Vol. 55
Issue 6
Pg. 979-83
(Dec 1993)
ISSN: 0916-7250 [Print] Japan |
PMID | 8117827
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Indans
- Sesquiterpenes
- Terpenes
- ptaquiloside
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Topics |
- Animal Feed
- Animals
- Bone Marrow
(pathology)
- Indans
- Male
- Photoreceptor Cells
(pathology)
- Plant Poisoning
(pathology, veterinary)
- Retina
(pathology)
- Retinal Degeneration
(etiology, pathology, veterinary)
- Sesquiterpenes
- Sheep
- Sheep Diseases
- Terpenes
(administration & dosage, isolation & purification, toxicity)
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