Abstract |
The biologic behavior of hemangiopericytoma is difficult to predict using clinical or histologic criteria. The authors studied 22 hemangiopericytomas (including " angioblastic meningiomas") from 16 patients. Included in the study were six recurrent tumors and one metastatic tumor. DNA flow cytometric analysis was performed on 21 tumors for which paraffin-embedded material was available. All of the tumors were DNA diploid. However, among patients with adequate follow-up information, all tumors that exhibited aggressive behavior (local recurrence, metastasis, death due to invasive disease) had S-phase fractions of greater than 9% and proliferative indices (S-phase plus G2M phase) of greater than 11%. There was also a trend toward aggressive behavior in tumors with necrotic foci. Tumors arising in the central nervous system behaved more aggressively than primary tumors at other sites. This study showed a trend toward more aggressive behavior in hemangiopericytomas with higher proliferative indices. DNA ploidy, however, was not a useful indicator of biologic behavior in these tumors.
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Authors | W G Finn, C L Goolsby, M S Rao |
Journal | American journal of clinical pathology
(Am J Clin Pathol)
Vol. 101
Issue 2
Pg. 181-5
(Feb 1994)
ISSN: 0002-9173 [Print] England |
PMID | 8116573
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Cell Division
- Central Nervous System Neoplasms
(genetics, pathology)
- DNA, Neoplasm
(analysis, metabolism)
- Female
- Flow Cytometry
- Hemangiopericytoma
(genetics, pathology)
- Humans
- Male
- Meningioma
(genetics, pathology)
- Middle Aged
- Pelvic Neoplasms
(genetics, pathology)
- Phenotype
- Ploidies
- S Phase
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