[Effect of veinotonyl 75 on the capillary permeability test using technetium albumin in cyclic orthostatic edemas].

Abstract

The purpose of this trial was to evaluate the clinical effect of Veinotonyl 75 in 42 women, 42 +/- 11 years old, with orthostatic cyclic edema. The main evaluation criterion was the result of a capillary filtration test with 99 mTc albumin which was performed at day 0 and at day 30 after treatment. At day 0, all the women had abnormal results ie an albumin retention > or = 8% (mean: 14.3% +/- 4.8%). At day 30, 75% of the patients were normalized in the Veinotonyl 75 group versus 38% in the placebo group (p < 0.02). The albumin retention in Veinotonyl 75 group was under the pathological level (mean: 5.2% +/- 4.8%) while it was over in the placebo group (mean: 9.4% +/- 7%). This study confirms the activity of Veinotonyl 75 on capillar protein hyperfiltration and on return venous circulation.

• Authors: A Behar, P Nathan, M Lavieuville, F A Allaert
• Journal: Phlebologie (Phlebologie) 1993 Oct-Dec Vol. 46 Issue 4 Pg. 721-31 ISSN: 0031-8280 [Print] France
• Vernacular Title: Effet du veinotonyl 75 sur le test de perméabilité capillaire a l'albumine technetiée dans les oedèmes cycliques orthostatiques.
• PMID: 8115491 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Plant Extracts
• Technetium Tc 99m Aggregated Albumin
• Veinotonyl 75

Topics

• Adult
• Capillary Permeability (drug effects)
• Double-Blind Method
• Edema (complications, diagnostic imaging, drug therapy, physiopathology)
• Female
• Humans
• Hypotension, Orthostatic (diagnostic imaging, drug therapy, physiopathology)
• Middle Aged
• Periodicity
• Plant Extracts (pharmacology, therapeutic use)
• Radionuclide Imaging
• Technetium Tc 99m Aggregated Albumin