[The effect of D-glucuronic acid on the regenerative processes of granulomonocytopoiesis in cytostatic-induced myelodepression].

Abstract

Whether cytostatic-induced disorders of the blood system can be corrected with D-glucuronic acid has been studied in murine experiments. D-glucuronic acid has been demonstrated to selectively stimulate the processes of bone marrow granulomonocytopoiesis both in intact animals and in rats with bone marrow hypoplasia induced by cyclophosphanum. During D-glucuronic acid administration, stimulation of hemopoietic regenerative processes is followed by the development of granulocyte lineage hyperplasia in bone marrow, the rapid restoration of blood polymorphonuclear leukocyte and monocyte counts and the development of neutrophilia and monocytosis.

• Authors: E D Gol'dberg, A M Dygaĭ, G V Karpova, E V Simanina, I A Khlusov, V P Shakhov, V I Agafonov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1993 Nov-Dec Vol. 56 Issue 6 Pg. 25-8 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Vliianie D-gliukuronovoĭ kisloty na protsessy regeneratsii granulomonotsitopoéza pri tsitostaticheskoĭ mielodepressii.
• PMID: 8111290 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Glucuronates
• Glucuronic Acid
• Cyclophosphamide

Topics

• Analysis of Variance
• Animals
• Bone Marrow (drug effects)
• Bone Marrow Cells
• Cell Division (drug effects)
• Cyclophosphamide (pharmacology)
• Depression, Chemical
• Drug Interactions
• Glucuronates (pharmacology)
• Glucuronic Acid
• Granulocytes (cytology, drug effects)
• Hematopoiesis (drug effects)
• Mice
• Mice, Inbred CBA
• Mitosis (drug effects)
• Monocytes (cytology, drug effects)
• Stimulation, Chemical
• Time Factors