Treatment of external genital warts comparing cryotherapy (liquid nitrogen) and trichloroacetic acid.

To evaluate and compare the efficacy and adverse effects of trichloracetic acid and cryotherapy (using liquid nitrogen) in the treatment of external genital warts.
Eighty-six patients were enrolled into a randomized clinical trial in the Genitourinary Medicine Department of the Coventry and Warwickshire Hospital (Coventry) between November 1990 and June 1991. External genital warts were treated with either trichloracetic acid or cryotherapy (using liquid nitrogen) on a once weekly basis. They received up to six treatments of either therapy.
Complete clearance of warts in patients who received up to six treatments of cryotherapy were observed in 86% of cases and in 70% of patients who received up to six treatments of trichloracetic acid. Thirty percent of patients who were treated with trichloracetic acid developed ulcerations at the site of its application.
In this study we found that cryotherapy (using liquid nitrogen) is more effective than that of trichloracetic acid for the treatment of external genital warts. It is also less likely to cause ulceration.
AuthorsA N Abdullah, M Walzman, A Wade
JournalSexually transmitted diseases (Sex Transm Dis) 1993 Nov-Dec Vol. 20 Issue 6 Pg. 344-5 ISSN: 0148-5717 [Print] UNITED STATES
PMID8108758 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Trichloroacetic Acid
  • Nitrogen
  • Condylomata Acuminata (drug therapy, therapy)
  • Cryotherapy (methods)
  • Female
  • Follow-Up Studies
  • Genital Diseases, Female (chemically induced, drug therapy, therapy)
  • Genital Diseases, Male (chemically induced, drug therapy, therapy)
  • Humans
  • Male
  • Nitrogen (therapeutic use)
  • Trichloroacetic Acid (adverse effects, therapeutic use)
  • Ulcer (chemically induced)

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