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The antibody response of vitamin A-deficient rats to pneumococcal polysaccharide is enhanced through coimmunization with lipopolysaccharide.

Abstract
Although the antibody response of vitamin A-deficient rats immunized with pneumococcal polysaccharide (SSS-III) was barely detectable, coimmunization with SSS-III plus 2 or 20 micrograms of Pseudomonas aeruginosa lipopolysaccharide (LPS) resulted in an anti-SSS-III response that was equal to or greater than that of vitamin A-sufficient rats immunized only with SSS-III. Doses of 2 and 20 micrograms of LPS, but not 0.1 and 0.5 micrograms, produced significant adjuvanticity, and LPS functioned as an adjuvant when given concomitantly with SSS-III (day 0) or up to 3 days later. Thus, vitamin A deficiency per se does not preclude the anti-SSS-III response, and LPS or factors released in response to LPS, even after initiation of the response to SSS-III, may substantially enhance antibody production to this thymus-independent, type 2 antigen.
AuthorsA M Pasatiempo, M Kinoshita, D T Foulke, A C Ross
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 169 Issue 2 Pg. 441-4 (Feb 1994) ISSN: 0022-1899 [Print] United States
PMID8106780 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Immunoglobulin M
  • Lipopolysaccharides
  • Polysaccharides, Bacterial
  • pneumococcal polysaccharide, type III
Topics
  • Animals
  • Antibodies, Bacterial (immunology)
  • Antibody-Producing Cells (immunology)
  • Antigens, Bacterial (immunology)
  • Female
  • Immunization Schedule
  • Immunoglobulin M (immunology)
  • Lipopolysaccharides (immunology)
  • Male
  • Polysaccharides, Bacterial (immunology)
  • Pseudomonas aeruginosa (immunology)
  • Rats
  • Rats, Inbred Lew
  • Streptococcus pneumoniae (immunology)
  • Vitamin A Deficiency (immunology)

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