Abstract |
Although the antibody response of vitamin A-deficient rats immunized with pneumococcal polysaccharide ( SSS-III) was barely detectable, coimmunization with SSS-III plus 2 or 20 micrograms of Pseudomonas aeruginosa lipopolysaccharide (LPS) resulted in an anti- SSS-III response that was equal to or greater than that of vitamin A-sufficient rats immunized only with SSS-III. Doses of 2 and 20 micrograms of LPS, but not 0.1 and 0.5 micrograms, produced significant adjuvanticity, and LPS functioned as an adjuvant when given concomitantly with SSS-III (day 0) or up to 3 days later. Thus, vitamin A deficiency per se does not preclude the anti- SSS-III response, and LPS or factors released in response to LPS, even after initiation of the response to SSS-III, may substantially enhance antibody production to this thymus-independent, type 2 antigen.
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Authors | A M Pasatiempo, M Kinoshita, D T Foulke, A C Ross |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 169
Issue 2
Pg. 441-4
(Feb 1994)
ISSN: 0022-1899 [Print] United States |
PMID | 8106780
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antibodies, Bacterial
- Antigens, Bacterial
- Immunoglobulin M
- Lipopolysaccharides
- Polysaccharides, Bacterial
- pneumococcal polysaccharide, type III
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Topics |
- Animals
- Antibodies, Bacterial
(immunology)
- Antibody-Producing Cells
(immunology)
- Antigens, Bacterial
(immunology)
- Female
- Immunization Schedule
- Immunoglobulin M
(immunology)
- Lipopolysaccharides
(immunology)
- Male
- Polysaccharides, Bacterial
(immunology)
- Pseudomonas aeruginosa
(immunology)
- Rats
- Rats, Inbred Lew
- Streptococcus pneumoniae
(immunology)
- Vitamin A Deficiency
(immunology)
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