[The possible neurochemical mechanisms of the neuroleptic action of buspirone-like serotonin agonists].

Abstract

The experiments on animals (rats and mice) and pigeons have established that buspirone and other serotonin agonists such as 1-(2-pyrimidinyl)-piperazine derivatives such as ipsapirone (TVX Q 7821), levopirone, kampirone, and sepirone have some pharmacological properties which are typical of neuroleptics. The serotonin agonists under study accelerate rat brain dopamine metabolism show their antagonism with apomorphine in the stereotypy and climbing tests in mice, suppress the conditioned avoidance reflex in rats, and eliminate apomorphine-induced vomiting in pigeons. Serotonin agonists, like serotonin, have been shown to stimulate the impulse-dependent release of 3H-dopamine from the slices of the rat nucleus accumbens and striatum. The capacity of buspirone and other serotonin antagonists of modulating dopamine release is not eliminated by 1A/B and 2 serotonin antagonists such as propranolol (3 microM) and metesergide (1 microM), but it is inhibited by ICS 205-930, a selective antagonist of 3HT receptors.

• Authors: N A Kharin, A T Dolzhenko, A V Titievskiĭ, S V Naletov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1993 Jul-Aug Vol. 56 Issue 4 Pg. 12-4 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Vozmozhnye neĭrokhimicheskie mekhanizmy neĭrolepticheskogo deĭstviia buspironopodobnykh agonistov serotonina.
• PMID: 8106056 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antipsychotic Agents
• Serotonin Receptor Agonists
• Apomorphine
• Buspirone
• Dopamine

Topics

• Aggression (drug effects)
• Animals
• Antipsychotic Agents (pharmacology)
• Apomorphine (antagonists & inhibitors, pharmacology)
• Behavior, Animal (drug effects)
• Brain (drug effects, metabolism)
• Buspirone (pharmacology)
• Columbidae
• Conditioning, Classical (drug effects)
• Dopamine (metabolism)
• Electric Stimulation
• In Vitro Techniques
• Male
• Mice
• Rats
• Serotonin Receptor Agonists (pharmacology)