Abstract |
Effects of IGN-2098 (5,6-dimethyl-2-[4-[3-(1-piperidinomethyl)phenoxy]- (z)-2-butenylamino]-4(1H)- pyrimidone dihydrochloride, CAS 126869-04-3) a novel histamine H2-antagonist, on histamine-induced gastric acid secretion were investigated in Heidenhain pouch dogs in comparison with those of famotidine, roxatidine acetate HCl and cimetidine. Orally administered IGN-2098 (0.03-1.0 mg/kg), famotidine (0.01-0.3 mg/kg), roxatidine acetate HCl (0.1-1.0 mg/kg) and cimetidine (0.3-3.0 mg/kg) showed dose-dependent inhibition on histamine-induced gastric acid secretion, and ED50 values of IGN-2098, famotidine, roxatidine acetate HCl and cimetidine were 0.077, 0.024, 0.200 and 0.585 mg/kg, respectively. IGN-2098 was effective even at 6 h after administration and ED50 value was 0.315 mg/kg. IGN-2098 was effective also by intravenous route. The inhibitory effect of IGN-2098 on histamine-induced gastric secretion was not affected by the repeated administration of IGN-2098 (1 mg/kg b.i.d. for 14 days). These results show that IGN-2098 is a potent and long acting antisecretory agent and is a useful antisecretory drug for the treatment of peptic ulcer disease.
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Authors | M Uchida, S Ohba, Y Ikarashi, N Misaki, O Kawano |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 43
Issue 8
Pg. 873-6
(Aug 1993)
ISSN: 0004-4172 [Print] Germany |
PMID | 8105784
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Histamine H2 Antagonists
- Piperidines
- Pyrimidinones
- IGN 2098
- Famotidine
- Cimetidine
- Histamine
- roxatidine acetate
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Topics |
- Administration, Oral
- Animals
- Cimetidine
(pharmacology)
- Dogs
- Dose-Response Relationship, Drug
- Famotidine
(pharmacology)
- Gastric Acid
(metabolism)
- Gastric Mucosa
(drug effects, metabolism)
- Histamine
(pharmacology)
- Histamine H2 Antagonists
(pharmacology)
- Injections, Intravenous
- Male
- Piperidines
(pharmacology)
- Pyrimidinones
(pharmacology)
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