Abstract | OBJECTIVES: DESIGN: Randomized, double-blind, controlled trial. SETTING: PATIENTS: INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: The success rate for 10-day treatment was 82% (14/17) compared with 55% (11/20) for 3-day treatment (P = .09). Among the 35 patients infected with Escherichia coli, all 10 patients infected with adhesin-negative isolates were treated successfully regardless of the duration of treatment, whereas only 14 (56%) of the 25 infections involving adhesin-positive isolates were clinically cured (P = .015). Two of the three failures in the 10-day treatment group were in patients with reflux. CONCLUSIONS:
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Authors | C E Johnson, J N Maslow, D C Fattlar, K S Adams, R D Arbeit |
Journal | American journal of diseases of children (1960)
(Am J Dis Child)
Vol. 147
Issue 10
Pg. 1090-3
(Oct 1993)
ISSN: 0002-922X [Print] United States |
PMID | 8105678
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Adhesins, Escherichia coli
- Bacterial Outer Membrane Proteins
- Clavulanic Acids
- Amoxicillin-Potassium Clavulanate Combination
- Amoxicillin
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Topics |
- Adhesins, Escherichia coli
- Amoxicillin
(therapeutic use)
- Amoxicillin-Potassium Clavulanate Combination
- Bacterial Adhesion
(genetics)
- Bacterial Outer Membrane Proteins
(genetics)
- Child, Preschool
- Clavulanic Acids
(therapeutic use)
- Double-Blind Method
- Drug Administration Schedule
- Drug Therapy, Combination
(therapeutic use)
- Escherichia coli
(genetics)
- Escherichia coli Infections
(drug therapy, microbiology)
- Female
- Humans
- Infant
- Male
- Operon
- Recurrence
- Treatment Outcome
- Urinary Tract Infections
(drug therapy, microbiology)
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