Abstract | BACKGROUND: METHODS: RESULTS: The positive expression of sialyl Lex was observed in 87 of 120 patients (72.5%). There was no statistically significant association between the negative or positive of sialyl Lex and clinicopathologic factors, excluding Dukes stage and histologic type. The difference between overall 5-year survival of patients with sialyl Lex-negative tumors and that of patients with sialyl Lex-positive tumors (81.2% versus 60.6%) was statistically significant (P = 0.0263). In proportion to staining intensity that was expressed as a score based on the percentage of the total field stained positive with CSLEX1, 5-year survival of patients indicated a worse outcome (P = 0.0113). The prognostic value was then studied in a Cox regression model. Dukes stage had the strongest association with patient survival, whereas sialyl Lex expression was found to be the second-ranking parameter. CONCLUSIONS:
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Authors | T Nakagoe, K Fukushima, M Hirota, H Kusano, H Ayabe, M Tomita, S Kamihira |
Journal | Cancer
(Cancer)
Vol. 72
Issue 8
Pg. 2323-30
(Oct 15 1993)
ISSN: 0008-543X [Print] United States |
PMID | 8104679
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Lewis X Antigen
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Topics |
- Adenocarcinoma
(metabolism, mortality, pathology)
- Aged
- Antibodies, Monoclonal
(immunology)
- Colorectal Neoplasms
(metabolism, mortality, pathology)
- Female
- Humans
- Immunohistochemistry
- Lewis X Antigen
(biosynthesis)
- Male
- Middle Aged
- Multivariate Analysis
- Neoplasm Staging
- Prognosis
- Proportional Hazards Models
- Survival Rate
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