Interactive potential of omega-3 fatty acids with clofibrate or DEHP on hepatic peroxisome proliferation in male Wistar rats.

Abstract

The interactive potential of three known peroxisome proliferators, omega-3 fatty acids, clofibrate and di(2-ethylhexylphthalate (DEHP), was evaluated in male weanling Wistar rats for the effect on peroxisomal beta-oxidation. Omega-3 fatty acids were supplied by menhaden oil which was fed in six regimens: low fat (5% w/w), low fat and clofibrate (0.3% w/w) or DEHP (0.25% w/w), high fat (20% w/w), high fat and clofibrate or DEHP in the aforementioned concentrations. Induction of peroxisomal beta-oxidation was measured by changes in liver-to-body weight ratio, fatty acyl-CoA oxidase (FAO) activity, and peroxisomal bifunctional enzyme (PBE) quantity. Analysis of transformed data indicated a less than additive response in FAO activity with no deviation from additivity seen with liver-to-body ratios and PBE.

• Authors: A M Wysynski, L A Baldwin, D A Leonard, E J Calabrese
• Journal: Human & experimental toxicology (Hum Exp Toxicol) Vol. 12 Issue 4 Pg. 337-40 (Jul 1993) ISSN: 0960-3271 [Print] England
• PMID: 8104013 (Publication Type: Journal Article)

Chemical References

• Dietary Fats
• Fatty Acids, Omega-3
• Multienzyme Complexes
• Diethylhexyl Phthalate
• Oxidoreductases
• 3-Hydroxyacyl CoA Dehydrogenases
• Acyl-CoA Oxidase
• Enoyl-CoA Hydratase
• Peroxisomal Bifunctional Enzyme
• Isomerases
• Clofibrate

Topics

• 3-Hydroxyacyl CoA Dehydrogenases (metabolism)
• Acyl-CoA Oxidase
• Animals
• Body Weight (drug effects)
• Cell Division (drug effects)
• Clofibrate (pharmacology)
• Dietary Fats (administration & dosage)
• Diethylhexyl Phthalate (pharmacology)
• Enoyl-CoA Hydratase (metabolism)
• Fatty Acids, Omega-3 (pharmacology)
• Isomerases (metabolism)
• Liver (drug effects, metabolism)
• Male
• Microbodies (drug effects, enzymology)
• Multienzyme Complexes (metabolism)
• Organ Size (drug effects)
• Oxidoreductases (metabolism)
• Peroxisomal Bifunctional Enzyme
• Rats
• Rats, Wistar