Chromosomal aberrations induced by methyl parathion in human peripheral lymphocytes of alcoholics and smokers.

Abstract

1 Two different concentrations (0.08 and 0.16 micrograms ml-1) of methyl parathion (MP), a broad-spectrum insecticide, were tested on peripheral lymphocytes of healthy non-smoking non-alcoholics (CN), chronic smokers (SM) and alcoholics with smoking habit (ALSM). 2 SM and ALSM revealed a significant increase in chromosome aberration frequencies in peripheral lymphocytes compared to the CN group. 3 MP did not induce chromosomal aberrations in vitro in the CN group at either of the concentrations tested. 4 In SM and ALSM, MP induced a significant increase in chromosomal aberrations in vitro in peripheral lymphocytes at a concentration of 0.16 micrograms ml-1. 5 The results indicate that the damage induced by MP in peripheral lymphocytes is potentiated by smoking and alcohol intake.

• Authors: K B Sunil Kumar, R Ankathil, K S Devi
• Journal: Human & experimental toxicology (Hum Exp Toxicol) Vol. 12 Issue 4 Pg. 285-8 (Jul 1993) ISSN: 0960-3271 [Print] England
• PMID: 8104005 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Parathion

Topics

• Alcoholism (genetics)
• Cells, Cultured
• Chromosome Aberrations
• Humans
• Male
• Parathion (adverse effects)
• Smoking (genetics)
• T-Lymphocytes (drug effects)