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The effect of bacteria infection on mean selected body temperature in the common Agama, agama agama: a dose-response study.

Abstract
1. The fever response was studied in 43 common agamas using a self-pairing experiment in which animals received an intraperitoneal injection of sterile saline and an injection of one of six dosages of dead Aeromonas sobria (1 x 10(6), 1 x 10(7), 1 x 10(8), 1 x 10(9), 1 x 10(10), and 1 x 10(11) total organisms). 2. The results demonstrated a significant increase in Tb (1.6-3.1 degrees C) above the mean selected body temperature (MSBT) of the saline injection animals over a bacteria infection range of three orders of magnitude. At 1 x 10(8) organisms, an increase was observed on bacteria day 1 while at dosages of 1 x 10(9) and 1 x 10(10) an increase was observed on bacteria days 1 and 2. 3. At dosages of 1 x 10(6) and 1 x 10(7) there was no difference between saline MSBT and bacteria MSBT. 4. At a dosage of 1 x 10(11), MSBTs on bacteria days 1 and 2 were below saline MSBT. 5. The average duration of the fever response is related to the level of infection; however, the magnitude of the fever is relatively independent of the level of infection.
AuthorsA B Ramos, M T Don, A E Muchlinski
JournalComparative biochemistry and physiology. Comparative physiology (Comp Biochem Physiol Comp Physiol) Vol. 105 Issue 3 Pg. 479-84 (Jul 1993) England
PMID8101779 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Topics
  • Aeromonas
  • Animals
  • Fever
  • Gram-Negative Bacterial Infections (physiopathology)
  • Lizards

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