Effects of bevantolol HCl on immobilization stress-induced hypertension and central beta-adrenoceptors in rats.

Abstract

Effects of chronic treatment with bevantolol, a beta-adrenoceptor blocker, and of repeated immobilization stress on blood pressure, body weight, and [3H]dihydroalprenolol ([3H]DHA) binding to the cerebral cortex were examined in rats. Systolic blood pressure increased to approximately 150 mmHg when stress was applied for 14 days (2 h day-1). This increase was inhibited by chronic treatment with bevantolol (250 mg kg-1 daily). However, bevantolol did not suppress the inhibition of body weight gain by stress. The maximum number of [3H]DHA binding sites (Bmax) in the cerebral cortex was decreased by stress without changing the affinity, and the decrease in Bmax mainly reflected the reduction of beta 1-adrenoceptors. Bevantolol treatment (250 mg kg-1) increased the Bmax to 137% and completely inhibited the downregulation of beta-adrenoceptors by stress. These results show that bevantolol can inhibit both the hypertension and downregulation of the central beta 1-adrenoceptors induced by stress.

• Authors: M Takita, S Kigoshi, I Muramatsu
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 45 Issue 3 Pg. 623-7 (Jul 1993) ISSN: 0091-3057 [Print] United States
• PMID: 8101379 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic beta-Antagonists
• Propanolamines
• bevantolol
• Dihydroalprenolol
• ICI 89406

Topics

• Adrenergic beta-Antagonists (pharmacology)
• Animals
• Blood Pressure (drug effects)
• Body Weight (drug effects)
• Cerebral Cortex (drug effects, metabolism)
• Dihydroalprenolol
• Down-Regulation (drug effects)
• Drinking (drug effects)
• Hypertension (etiology, physiopathology)
• Immobilization
• Male
• Propanolamines (blood, pharmacology)
• Rats
• Rats, Wistar
• Stress, Psychological (complications, metabolism, physiopathology)