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[Tendency of development on novel type of cardiotonic drugs].

Abstract
The narrow margin of safety of cardiotonic glycosides has led to extensive studies for novel cardiotonic agents that are superior to the glycosides. Cardiotonic drugs acting on beta-adrenoceptors and inhibitors of cAMP phosphodiesterase have been extensively studied and used for the treatment of heart failure. Ca sensitizers are of interest, since such a mechanism of action may be beneficial for the failing heart. Recently, cardiotonic substances with a novel mechanism of action such as gingerol and xestoquinone have been isolated from natural sources. Furthermore, 9-methyl-7-bromoeudistomin D, a powerful radiolabeled Ca2+ releaser having caffeine-like properties, may provide a promising tool for studying the molecular mechanism of the Ca2+ release process.
AuthorsY Ohizumi
JournalNihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 51 Issue 5 Pg. 1299-304 (May 1993) ISSN: 0047-1852 [Print] Japan
PMID8101238 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Adrenergic beta-Agonists
  • Catechols
  • Fatty Alcohols
  • Pyridazines
  • Troponin
  • Dobutamine
  • gingerol
  • MCI 154
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Amrinone
  • Calcium
  • Dopamine
Topics
  • 3',5'-Cyclic-AMP Phosphodiesterases (antagonists & inhibitors)
  • Adrenergic beta-Agonists (therapeutic use)
  • Amrinone (therapeutic use)
  • Animals
  • Calcium (metabolism)
  • Catechols
  • Dobutamine (therapeutic use)
  • Dopamine (therapeutic use)
  • Fatty Alcohols (pharmacology, therapeutic use)
  • Heart Failure (drug therapy)
  • Humans
  • Pyridazines (therapeutic use)
  • Troponin (metabolism)

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