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Effect of vanadyl sulfate feeding on susceptibility to peroxidative change in diabetic rats.

Abstract
The effects of vanadyl sulfate treatment on susceptibility to oxidative stress were investigated in streptozotocin-diabetic Wistar rats. A 2 x 2 factorial design was employed, with four groups of animals: 1) untreated, non-diabetic; 2) vanadyl-treated, non-diabetic; 3) untreated, diabetic; and 4) vanadyl-treated, diabetic. Vanadyl sulfate was administered as a 1.00 to 1.25 mg/ml solution in drinking water. Cataract development was entirely suppressed in vanadyl-treated compared to untreated, diabetic rats. STZ-induction of diabetes diminished glutathione (GSH) levels in liver homogenates; whereas vanadyl treatment resulted in restored levels of this nonenzymatic antioxidant. Thiobarbituric acid reactive substances (TBARS), both basal and iron-stimulated, were significantly elevated in all vanadyl-treated animals. Vanadyl treatment lowered liver glutamine synthetase activities in diabetic rats, but not in non-diabetic animals. Thus, vanadyl treatment was antioxidant in terms of cataract formation and reduced glutathione concentration in liver homogenates, pro-oxidant by reason of iron-stimulated TBARS formation and inconclusive with respect to glutamine synthetase activity. These results highlight the importance of using multiple indicators of peroxidative change in evaluating new pro-oxidant/antioxidant treatment regimens.
AuthorsK H Thompson, J H McNeill
JournalResearch communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 80 Issue 2 Pg. 187-200 (May 1993) ISSN: 0034-5164 [Print] United States
PMID8100638 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Thiobarbituric Acid Reactive Substances
  • Vanadium Compounds
  • Vanadium
  • Streptozocin
  • vanadyl sulfate
  • Glutamate-Ammonia Ligase
  • Glutathione
Topics
  • Administration, Oral
  • Animals
  • Cataract (metabolism)
  • Diabetes Mellitus, Experimental (metabolism)
  • Glutamate-Ammonia Ligase (metabolism)
  • Glutathione (metabolism)
  • Lipid Peroxidation (drug effects)
  • Liver (drug effects, enzymology)
  • Male
  • Rats
  • Rats, Wistar
  • Streptozocin
  • Thiobarbituric Acid Reactive Substances (metabolism)
  • Vanadium (metabolism, pharmacology)
  • Vanadium Compounds

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