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Effects on food and water intake of the alpha 1-adrenoceptor agonists amidephrine and SK&F-89748.

Abstract
Activation of alpha-1 adrenoceptors, via systemic injection of agonists such as cirazoline and phenylpropanolamine (PPA), reliably suppresses food intake in rats. These effects are thought to result from stimulation of central alpha 1-adrenoceptors within the rat paraventricular hypothalamic nucleus (PVN), based on studies in which direct injections of cirazoline, methoxamine, phenylephrine and PPA into PVN suppress food intake. Because relatively few alpha 1-agonists have been tested to date using the systemic route of exposure, the present study examined the effects of the alpha 1-adrenoceptor agonists amidephrine and SKF-89748 on food and water intake. Adult male rats received systemic injections (IP) of either amidephrine (0.025, 0.05, 0.01 mg/kg) or of SK&F 89748 (0.01, 0.02, and 0.04 mg/kg). Amidephrine markedly suppressed food intake (ED50 = 0.49 mg/kg) and water intake (ED50 = 0.50 mg/kg), while SK&F 89748 marginally suppressed food intake (ED50 = 0.37 mg/kg) and was less potent in suppressing water intake (ED50 = 0.76 mg/kg). These results document that systemic injection of the alpha 1-adrenoceptor agonists amidephrine and SK&F 89748 induces anorexia with amidephrine exerting greater potency than SK&F 89748. These results further support the hypothesis that stimulation of alpha 1-adrenoceptors suppresses food intake.
AuthorsA Morien, L McMahon, P J Wellman
JournalLife sciences (Life Sci) Vol. 53 Issue 2 Pg. 169-74 ( 1993) ISSN: 0024-3205 [Print] Netherlands
PMID8100042 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adrenergic alpha-Agonists
  • Ethanolamines
  • Tetrahydronaphthalenes
  • amidephrine
  • SK&F 89748
Topics
  • Adrenergic alpha-Agonists (pharmacology)
  • Analysis of Variance
  • Animals
  • Drinking Behavior (drug effects)
  • Ethanolamines (pharmacology)
  • Feeding Behavior (drug effects)
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Tetrahydronaphthalenes (pharmacology)

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