Abstract |
The effects of a series of D- and L- amino acid alcohols on the proliferation and phenotypic expression of B16 mouse melanoma cells were evaluated. B16 melanoma cells were incubated for different time intervals in the presence of D- or L- phenylalaninol (PHE), D- or L- alaninol (AL), D- or L- leucinol (LE), L- histidinol (HIS), L- tyrosinol (TYR) and L- methioninol (MET). All agents, including the D or L configuration, induced an anti-proliferative effect, although of considerably different magnitude. D-PHE was the most active growth inhibitor. The growth inhibitory effects were accompanied by phenotypic alterations, which included morphological changes and enhancement in the activities of NADPH cytochrome c reductase and tau- glutamyl transpeptidase. These phenotypic alterations correlated with the growth inhibitory effects of the different agents and seem to reflect a higher differentiated state.
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Authors | O Landau, L Wasserman, A A Deutsch, R Reiss, H Panet, A Novogrodsky, J Nordenberg |
Journal | Cancer letters
(Cancer Lett)
Vol. 69
Issue 3
Pg. 203-8
(May 14 1993)
ISSN: 0304-3835 [Print] Ireland |
PMID | 8099846
(Publication Type: Journal Article)
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Chemical References |
- Amino Alcohols
- NADPH-Ferrihemoprotein Reductase
- gamma-Glutamyltransferase
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Topics |
- Amino Alcohols
(pharmacology)
- Animals
- Cell Division
(drug effects)
- Enzyme Induction
(drug effects)
- Melanoma, Experimental
(enzymology, pathology)
- Mice
- NADPH-Ferrihemoprotein Reductase
(biosynthesis)
- Phenotype
- gamma-Glutamyltransferase
(biosynthesis)
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