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Amino acid alcohols: growth inhibition and induction of differentiated features in melanoma cells.

Abstract
The effects of a series of D- and L-amino acid alcohols on the proliferation and phenotypic expression of B16 mouse melanoma cells were evaluated. B16 melanoma cells were incubated for different time intervals in the presence of D- or L-phenylalaninol (PHE), D- or L-alaninol (AL), D- or L-leucinol (LE), L-histidinol (HIS), L-tyrosinol (TYR) and L-methioninol (MET). All agents, including the D or L configuration, induced an anti-proliferative effect, although of considerably different magnitude. D-PHE was the most active growth inhibitor. The growth inhibitory effects were accompanied by phenotypic alterations, which included morphological changes and enhancement in the activities of NADPH cytochrome c reductase and tau-glutamyl transpeptidase. These phenotypic alterations correlated with the growth inhibitory effects of the different agents and seem to reflect a higher differentiated state.
AuthorsO Landau, L Wasserman, A A Deutsch, R Reiss, H Panet, A Novogrodsky, J Nordenberg
JournalCancer letters (Cancer Lett) Vol. 69 Issue 3 Pg. 203-8 (May 14 1993) ISSN: 0304-3835 [Print] Ireland
PMID8099846 (Publication Type: Journal Article)
Chemical References
  • Amino Alcohols
  • NADPH-Ferrihemoprotein Reductase
  • gamma-Glutamyltransferase
Topics
  • Amino Alcohols (pharmacology)
  • Animals
  • Cell Division (drug effects)
  • Enzyme Induction (drug effects)
  • Melanoma, Experimental (enzymology, pathology)
  • Mice
  • NADPH-Ferrihemoprotein Reductase (biosynthesis)
  • Phenotype
  • gamma-Glutamyltransferase (biosynthesis)

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