Anorexia following the systemic injection of amylin.

Abstract

The intravenous injection of 100 micrograms/kg of rat amylin reduced food intake in schedule-fed rats for 1 h of an 8 h measurement period. Associated with this brief anorexia was a hyperglycemic response, observed 30 min after a subsequent amylin administration. Determination of neurochemical alterations revealed increased concentration of serotonin in the hypothalamus and decreased level of the dopamine metabolite, 3-methoxytyramine, in the corpus striatum. Since similar neurochemical alterations were observed following the systemic injection of glucose, both the neurochemical changes and anorexia following intravenous amylin treatment may be secondary to hyperglycemia.

• Authors: W T Chance, A Balasubramaniam, A Stallion, J E Fischer
• Journal: Brain research (Brain Res) Vol. 607 Issue 1-2 Pg. 185-8 (Apr 02 1993) ISSN: 0006-8993 [Print] Netherlands
• PMID: 8097662 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Amyloid
• Blood Glucose
• Islet Amyloid Polypeptide
• Neurotransmitter Agents
• Glucose

Topics

• Amyloid (administration & dosage, antagonists & inhibitors, pharmacology)
• Animals
• Anorexia (chemically induced)
• Blood Glucose (metabolism)
• Brain Chemistry (drug effects)
• Corpus Striatum (drug effects, metabolism)
• Feeding Behavior (drug effects)
• Glucose (pharmacology)
• Hypothalamus (drug effects, metabolism)
• Injections, Intravenous
• Islet Amyloid Polypeptide
• Male
• Neurotransmitter Agents (metabolism)
• Rats
• Rats, Sprague-Dawley