[Effects of inhaled beta-adrenergic and anticholinergic drugs on respiratory function and arterial blood gases in patients with pulmonary emphysema].

Abstract

We studied the effects of inhaled anticholinergic (oxitropium bromide, 0.2 mg) and beta-adrenergic (fenoterol 0.4 mg) drugs on respiratory function and arterial blood gases in fourteen male patients with pulmonary emphysema (age 63 +/- 8 years; FEV1/FVC 1.41 +/- 0.73 L) using a three day, randomized, double-blind placebo-controlled design. Each day, spirometry and arterial blood gas analyses were performed before and 45 min after inhalation. Both fenoterol and oxitropium bromide significantly improved FEV1 by 21% and 16%, respectively, although there was no significant difference between the two drugs. However, the mean value of PaO2 significantly decreased from 74.5 +/- 2.6 to 69.3 +/- 2.7 Torr with fenoterol, but not with oxitropium and placebo. Change of PaO2 with fenoterol was significantly correlated with %FRC, but not with FEV1 nor change of FEV1. We therefore conclude that an anticholinergic inhalant bronchodilator is more favorable for patients with COPD than a beta-adrenergic agent.

• Authors: T Igarashi, M Nishimura, Y Akiyama, M Yamamoto, S Kobayashi, K Miyamoto, Y Kawakami
• Journal: Nihon Kyobu Shikkan Gakkai zasshi (Nihon Kyobu Shikkan Gakkai Zasshi) Vol. 31 Issue 1 Pg. 32-6 (Jan 1993) ISSN: 0301-1542 [Print] Japan
• PMID: 8096880 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Adrenergic beta-Agonists
• Parasympatholytics
• Scopolamine Derivatives
• Fenoterol
• oxitropium
• Oxygen

Topics

• Adrenergic beta-Agonists (pharmacology, therapeutic use)
• Aged
• Aged, 80 and over
• Double-Blind Method
• Fenoterol (pharmacology, therapeutic use)
• Forced Expiratory Volume (drug effects)
• Humans
• Male
• Middle Aged
• Oxygen (blood)
• Parasympatholytics (pharmacology, therapeutic use)
• Partial Pressure
• Pulmonary Emphysema (blood, drug therapy, physiopathology)
• Scopolamine Derivatives (pharmacology, therapeutic use)