Structural features of two T-cell-specific genes that suggest a potential role in HTLV-I-associated pathology.

Abstract

The Rpt-1 gene product is an intranuclear protein expressed by CD4+ T-cells, which may regulate expression of the interleukin-2 receptor. Structural analysis of Rpt-1 reveals structural motifs that are shared by a group of transcriptional regulatory proteins with oncogenic potential. We suggest that altered expression of Rpt-1 may be associated with HTLV-I-dependent T-cell leukemias.

• Authors: R Patarca, M A Fletcher, H Cantor
• Journal: AIDS research and human retroviruses (AIDS Res Hum Retroviruses) Vol. 9 Issue 2 Pg. 105-7 (Feb 1993) ISSN: 0889-2229 [Print] United States
• PMID: 8096144 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Autoantigens
• Neoplasm Proteins
• Nuclear Proteins
• RNA, Small Cytoplasmic
• RO60 protein, human
• Ribonucleoproteins
• SS-A antigen

Topics

• Amino Acid Sequence
• Animals
• Autoantigens (genetics)
• CD4-Positive T-Lymphocytes (metabolism)
• Humans
• Leucine Zippers (genetics)
• Leukemia-Lymphoma, Adult T-Cell (genetics, immunology)
• Mice
• Molecular Sequence Data
• Neoplasm Proteins (genetics)
• Nuclear Proteins (genetics)
• RNA, Small Cytoplasmic
• Ribonucleoproteins (genetics)
• Sequence Homology, Amino Acid
• T-Lymphocytes (immunology, metabolism)
• Zinc Fingers (genetics)