Effects of beta-adrenergic blockers on drug-induced tremors.

Abstract

We studied the effect of various kinds of beta-adrenergic blockers on oxotremorine-, harmaline- and thyrotropin-releasing hormone (TRH)-induced tremors in mice. To investigate what property of beta-blockers plays the main role in suppressing tremor, we employed five beta-blockers (propranolol, atenolol, butoxamine, pindolol, and arotinolol). All drugs suppressed oxotremorine-induced tremors but none reduced harmaline-induced tremors. Even though TRH-induced tremors were decreased significantly only by propranolol and high doses of arotinolol, all drugs had a tendency to reduce the tremor. We concluded that neuropharmacological mechanisms underlying to harmaline-induced tremors were different from those of TRH- and oxotremorine-induced tremors and that features of beta-blockers (beta 1- or beta 2-selectivity, intrinsic sympathomimetic activity, and membrane stabilizing activity) did not primarily contribute to the suppression of tremors.

• Authors: S Iwata, M Nomoto, T Fukuda
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 44 Issue 3 Pg. 611-3 (Mar 1993) ISSN: 0091-3057 [Print] United States
• PMID: 8095722 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Oxotremorine
• Thyrotropin-Releasing Hormone
• Harmaline

Topics

• Adrenergic beta-Antagonists (pharmacology)
• Animals
• Fourier Analysis
• Harmaline
• Male
• Mice
• Mice, Inbred Strains
• Oxotremorine
• Thyrotropin-Releasing Hormone
• Tremor (chemically induced, prevention & control)