Association between genetic variation at the porphobilinogen deaminase gene and schizophrenia.

Abstract

There is growing evidence that some genetic predisposition is important in the etiology of schizophrenia. We have sought to implicate a major gene by performing a candidate gene association study comparing the allele frequencies of seven restriction fragment length polymorphisms (RFLPs) at six loci in both a psychiatrically normal control group (N = 51) and an affected (schizophrenia or schizoaffective disorder) group (N = 55). Each group comprised Caucasians of northern European origin. The candidate areas (D5S39, D5S78, dopamine receptor D2 (DRD2), D11S29, porphobilinogen deaminase (PBGD), and D11S84) were selected on the basis of prior cytogenetic findings in schizophrenics, linkage studies, and/or implicated gene products. The presence of a polymorphic ApaLI site within the PBGD gene showed a significant association with the presence of illness (P = 0.02). The relative risk of possessing the allele with the ApaLI site was 2.10. No significant association was found with any of the six other RFLPs. Our data suggests that either the PBGD gene itself or an unknown gene linked to and/or in linkage disequilibrium with the PBGD locus predisposes some individuals to schizophrenia. Independent replication of these findings will be required to determine their relevance to schizophrenia.

• Authors: A R Sanders, D E Rincon-Limas, R Chakraborty, B Grandchamp, J D Hamilton, W E Fann, P I Patel
• Journal: Schizophrenia research (Schizophr Res) Vol. 8 Issue 3 Pg. 211-21 (Jan 1993) ISSN: 0920-9964 [Print] Netherlands
• PMID: 8094629 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hydroxymethylbilane Synthase
• Deoxyribonucleases, Type II Site-Specific
• GTGCAC-specific type II deoxyribonucleases

Topics

• Adolescent
• Adult
• Alleles
• Chromosome Mapping
• Deoxyribonucleases, Type II Site-Specific (genetics)
• Female
• Gene Frequency (genetics)
• Genetic Carrier Screening
• Genetic Linkage (genetics)
• Genetic Variation
• Humans
• Hydroxymethylbilane Synthase (genetics)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Restriction Fragment Length
• Psychiatric Status Rating Scales
• Schizophrenia (diagnosis, genetics)
• Schizophrenic Psychology