| Abstract | High-dosage intravenous human immunoglobulin G (i.v. IgG) has been used with varying degrees of success to treat a variety of auto-immune disorders which are frequently characterized by a predominantly pathogenic auto-antibody. The present report, in which consistent control and ultimately complete remission of a resistant auto-immune haemolytic anaemia (AIHA) was achieved by carrying out preliminary plasma exchange as a crucial prelude to the administration of high-dose i.v. IgG provides not only insight into the immuno-regulatory action of the IgG but also raises the interesting possibility that similar benefit might be obtained by such combined procedures in other resistant auto-immune diseases. |
| Authors | P Hughes, A Toogood
(Affiliation: Department of Medicine, University of Sheffield, Northern General Hospital, UK.)
|
| Journal | Acta haematologica
(Acta Haematol)
Vol. 91
Issue 3
Pg. 166-9
( 1994)
ISSN: 0001-5792 SWITZERLAND |
| PMID | 8091939
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Immunoglobulins, Intravenous
|
| Topics |
- Aged
- Anemia, Hemolytic, Autoimmune
(therapy)
- Female
- Humans
- Immunoglobulins, Intravenous
(therapeutic use)
- Plasma Exchange
|
