Infection of leucocytes by measles vaccine viruses Edmonston-Zagreb and Enders-Moraten has different consequences: potential mechanism for increased vaccine efficacy or aberrant activity in field trials.
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| Abstract |
The abilities of two measles vaccine virus strains, Edmonston-Zagreb (E-Z) and Enders-Moraten (E-M), to infect and modify the activities of U937 monocytoid and peripheral blood mononuclear leucocytes (PBMLs) were compared with each other and with changes resulting from infection of these cells by a wild-type measles virus (MV). Both the E-Z and wild-type MV were shown to infect U937 and PBMLs and (1) to markedly increase expression of leucocyte function antigen 1 (LFA-1) on leucocytes present in infected cultures; (2) to increase cell-cell interaction; (3) to grow and disseminate readily in both types of leucocyte cultures; and (4) to persist for more than 7 days in these cultures despite the presence of MV-specific neutralizing antibodies. In contrast, the E-M virus did not grow well in unstimulated PBMLs and, although it did grow well in U937 cells, it did not noticeably alter the expression of LFA-1 on these cells, did not induce significant cell-cell interaction, and was rapidly eliminated from these cultures if MV-specific neutralizing antibodies were present. The possible relationship of these findings to the increased protective efficacy and untoward effects associated with the E-Z MV vaccine is discussed.
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| Authors | P R Wyde, N R Attibele, W L Kemp |
| Journal | Vaccine (Vaccine) Vol. 12 Issue 8 Pg. 715-22 (Jun 1994) ISSN: 0264-410X [Print] Netherlands |
| PMID | 8091849 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.) |
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