Four-week toxicity study of 4-methoxytoluene in rats.

Abstract

4-Methoxytoluene was given by gavage to 4 groups of 20 rats at dosage levels of 0, 40, 120 or 240 mg kg-1 body weight/day for 4 weeks. There was a statistically significant decrease in serum creatinine and urea in the intermediate and high dose group for both sexes. Among males, a statistically significant decrease in the packed cell volume was observed in the high and intermediate dose group. A no-observed-effect level of 40 mg kg-1 body weight/day was determined.

• Authors: B Brunsborg, O Meyer, G Würtzen, P Olsen
• Journal: Toxicology letters (Toxicol Lett) Vol. 73 Issue 3 Pg. 209-12 (Sep 1994) ISSN: 0378-4274 [Print] Netherlands
• PMID: 8091429 (Publication Type: Journal Article)

Chemical References

• Anisoles
• Flavoring Agents
• 4-methyl anisole
• Urea
• Creatinine

Topics

• Administration, Oral
• Analysis of Variance
• Animals
• Anisoles (administration & dosage, toxicity)
• Body Weight (drug effects)
• Creatinine (blood)
• Dose-Response Relationship, Drug
• Drinking (drug effects)
• Eating (drug effects)
• Erythrocytes (drug effects)
• Female
• Flavoring Agents (toxicity)
• Male
• Rats
• Rats, Wistar
• Sex Characteristics
• Urea (blood)