Effects of a novel compound MCI-225 on impaired learning and memory in rats.

Abstract

Effects of MCI-225, [4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-d]pyrimidine monohydrate hydrochloride] on experimental amnesia were studied in rats and compared with those of THA [9-amino-1,2,3,4-tetrahydroacridine]. In the Morris-type water maze task, MCI-225 (1-10 mg/kg, PO) reduced the spatial learning impairment induced by scopolamine (0.5 mg/kg, IP). In a passive avoidance (PA) task, administration of MCI-225 prior to training (1-30 mg/kg, PO) lessened the carbon dioxide (CO2)-induced amnesia in a dose-dependent manner. MCI-225 (1-100 mg/kg) did not affect gross behavior. THA (0.1-3 mg/kg, PO) reduced scopolamine-induced learning deficits in the water maze task, but the effect was not significant. THA (0.3-3 mg/kg, PO) also ameliorated the CO2-induced amnesia, although slightly, in the PA task. THA (10 mg/kg, PO) increased locomotor activity and higher dose of THA (30 mg/kg, PO) induced tremor, hypersalivation, and muscle relaxation. These results suggest that MCI-225 lessens impairments in learning and memory without causing serious behavioral abnormalities.

• Authors: J Eguchi, T Yuasa, M Egawa, A Tobe
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 48 Issue 2 Pg. 345-9 (Jun 1994) ISSN: 0091-3057 [Print] United States
• PMID: 8090800 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cholinesterase Inhibitors
• Piperazines
• Psychotropic Drugs
• Pyrimidines
• MCI 225
• Carbon Dioxide
• Tacrine
• Scopolamine

Topics

• Animals
• Avoidance Learning (drug effects)
• Behavior, Animal (drug effects)
• Carbon Dioxide
• Cholinesterase Inhibitors (pharmacology)
• Learning Disabilities (chemically induced, drug therapy, psychology)
• Male
• Memory Disorders (chemically induced, drug therapy, psychology)
• Motor Activity (drug effects)
• Orientation (drug effects)
• Piperazines (therapeutic use)
• Psychotropic Drugs (therapeutic use)
• Pyrimidines (therapeutic use)
• Rats
• Rats, Wistar
• Scopolamine
• Tacrine (pharmacology)