The Fibrel mechanism of action study. A preliminary report.

Abstract

BACKGROUND:

Fibrel is a medical implant device that has demonstrated use in the correction of cutaneous depressions from acne scars and wrinkles.

OBJECTIVE:

Mechanisms of actions have been proposed that have theorized the production of new collagen over time as a result of the Fibrel implant. The present study utilized human volunteers to study the histologic response of Fibrel over time.

METHODS:

Fibrel was injected into tattoo sites behind the ears of human volunteers; skin biopsies were taken at various time intervals and studied histologically by a clinical pathologist.

RESULTS:

An overall increase over time was noted with regard to production of collagen and inflammatory response. No change in elastic tissue was found.

CONCLUSIONS:

Fibrel does promote new collagen synthesis and inflammatory response and thus is useful to correct cutaneous depressions via soft tissue augmentation.

• Authors: M H Gold
• Journal: The Journal of dermatologic surgery and oncology (J Dermatol Surg Oncol) Vol. 20 Issue 9 Pg. 586-90 (Sep 1994) ISSN: 0148-0812 [Print] United States
• PMID: 8089358 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aminocaproates
• Fibrel
• Gelatin
• Collagen

Topics

• Adult
• Aminocaproates (administration & dosage, pharmacology)
• Collagen (metabolism)
• Connective Tissue (drug effects, pathology, surgery)
• Dermatologic Surgical Procedures
• Elastic Tissue (drug effects, pathology)
• Female
• Gelatin (administration & dosage, pharmacology)
• Humans
• Inflammation (pathology)
• Injections, Intradermal
• Male
• Middle Aged
• Prostheses and Implants
• Skin (drug effects, pathology)
• Time Factors