Abstract | PURPOSE: METHODS: RESULTS:
Congo red and antisera to AP and AGel bound to amyloid deposits in the cornea and conjunctiva, the sclera, the perineurium of ciliary nerves, the walls of ciliary vessels, the optic nerve sheaths, the stroma of the ciliary body, and along the choriocapillaris. mAb GS-2C4 bound weakly and focally to most deposits and strongly around the choriocapillaris. It labeled the corneal epithelium and endothelium, keratocytes, scleral fibroblasts, trabecular and lens epithelial cells, the ciliary muscle and epithelium, the iris sphincter and dilator, and stromal cells of the conjunctiva and uveal tract. CONCLUSIONS: Local production, especially in the cornea, conjunctiva, sclera, and ciliary muscle, and systemic deposition, particularly in blood vessles and in the sclera, may contribute to amyloid deposits in FAF. To explain the complex pattern of deposition, microenvironmental factors such as lamellar architecture of the cornea and sclera, altered processing of gelsolin, or blood-tissue barriers must be invoked. In addition to corneal lattice dystrophy type II, the observed deposits help to explain glaucoma in patients with FAF.
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Authors | T Kivelä, A Tarkkanen, B Frangione, J Ghiso, M Haltia |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 35
Issue 10
Pg. 3759-69
(Sep 1994)
ISSN: 0146-0404 [Print] United States |
PMID | 8088963
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Amyloid
(metabolism)
- Amyloidosis
(genetics, metabolism, pathology)
- Anterior Eye Segment
(blood supply, innervation, metabolism, pathology)
- Choroid
(metabolism, pathology)
- Eye Diseases
(genetics, metabolism, pathology)
- Finland
- Gelsolin
(metabolism)
- Humans
- Immunoenzyme Techniques
- Middle Aged
- Optic Nerve
(metabolism, pathology)
- Retina
(metabolism, pathology)
- Syndrome
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