Mouse thioredoxin gene maps on chromosome 4, whereas its pseudogene maps on chromosome 1.

Abstract

Thioredoxins are involved in various biochemical systems and mediate both redox and nonredox functions. In mammalian cells, thioredoxin functions as an endogenous glucocorticoid receptor activating factor and as an adult T-cell leukemia-derived factor (ADF) that stimulates expression of interleukin-2 receptor in human T-cell leukemia virus (HTLV)-I transformed T cells. We have mapped the thioredoxin gene (Txn) and its processed pseudogene (Txn-ps1) in the mouse using a panel of interspecific backcross mice. Txn maps to Chr 4, whereas Txn-ps1 maps to the proximal region of Chr 1.

• Authors: M Taketo, M Matsui, J M Rochelle, J Yodoi, M F Seldin
• Journal: Genomics (Genomics) Vol. 21 Issue 1 Pg. 251-3 (May 01 1994) ISSN: 0888-7543 [Print] United States
• PMID: 8088797 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Thioredoxins

Topics

• Animals
• Chromosome Mapping
• Crosses, Genetic
• Genes
• Humans
• Meiosis
• Mice (genetics)
• Mice, Inbred C3H
• Muridae (genetics)
• Pseudogenes
• Species Specificity
• Thioredoxins (genetics)