Abstract |
We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concentrations ranging between 8.5 and 10 g/dl. In the literature, such rarely encountered hemolyzing warm-reacting agglutinins are described as causing severe hemolysis with a frequently fatal clinical outcome.
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Authors | T Fest, B de Wazières, B Lamy, M Maskani, D Vuitton, J L Dupond |
Journal | Annals of hematology
(Ann Hematol)
Vol. 69
Issue 3
Pg. 147-9
(Sep 1994)
ISSN: 0939-5555 [Print] Germany |
PMID | 8086510
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Autoantibodies
- Hemoglobins
- Immunoglobulin M
- Interferon alpha-2
- Interferon-alpha
- Recombinant Proteins
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Topics |
- Aged
- Anemia, Hemolytic, Autoimmune
(immunology, therapy)
- Autoantibodies
(immunology)
- Female
- Hemagglutination
- Hemoglobins
(metabolism)
- Humans
- Immunoglobulin M
(immunology)
- Interferon alpha-2
- Interferon-alpha
(therapeutic use)
- Recombinant Proteins
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