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Successful response to alpha-interferon 2b in a refractory IgM autoagglutinin-mediated hemolytic anemia.

Abstract
We describe the beneficial effect of recombinant alpha 2b interferon in a woman with an idiopathic and refractory IgM-mediated autoimmune hemolytic anemia due to low-titer, high-thermal-amplitude cold agglutinins. The response was partial but sustained, 2 months after interruption of interferon, with hemoglobin concentrations ranging between 8.5 and 10 g/dl. In the literature, such rarely encountered hemolyzing warm-reacting agglutinins are described as causing severe hemolysis with a frequently fatal clinical outcome.
AuthorsT Fest, B de Wazières, B Lamy, M Maskani, D Vuitton, J L Dupond
JournalAnnals of hematology (Ann Hematol) Vol. 69 Issue 3 Pg. 147-9 (Sep 1994) ISSN: 0939-5555 [Print] Germany
PMID8086510 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Autoantibodies
  • Hemoglobins
  • Immunoglobulin M
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
Topics
  • Aged
  • Anemia, Hemolytic, Autoimmune (immunology, therapy)
  • Autoantibodies (immunology)
  • Female
  • Hemagglutination
  • Hemoglobins (metabolism)
  • Humans
  • Immunoglobulin M (immunology)
  • Interferon alpha-2
  • Interferon-alpha (therapeutic use)
  • Recombinant Proteins

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