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Carcinogenic evaluation of 2,3-dimethyl-2,3-dinitrobutane via the mouse skin bioassay.

Abstract
Female SENCAR mice initiated with 2,3-dimethyl-2,3-dinitrobutane (DMDNB) and promoted with 12-O-tetradecanoylphorol-13-acetate (TPA) via the SENCAR mouse skin bioassay did not exhibit a significant increase in skin tumors. The mice received 20 mg kg-1 DMDNB divided into six intragastric doses over 2 weeks and were promoted three times per week for 20 weeks.
AuthorsT V Reddy, G R Olson, F B Daniel, M Robinson
JournalJournal of applied toxicology : JAT (J Appl Toxicol) 1994 May-Jun Vol. 14 Issue 3 Pg. 231-2 ISSN: 0260-437X [Print] England
PMID8083485 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Butanes
  • Carcinogens
  • 2,3-dimethyl-2,3-dinitrobutane
Topics
  • Animals
  • Butanes (toxicity)
  • Carcinogenicity Tests (methods)
  • Carcinogens (toxicity)
  • Female
  • Mice
  • Mice, Inbred Strains
  • Skin Neoplasms (chemically induced)

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