Abstract |
Female SENCAR mice initiated with 2,3-dimethyl-2,3-dinitrobutane ( DMDNB) and promoted with 12-O-tetradecanoylphorol-13-acetate (TPA) via the SENCAR mouse skin bioassay did not exhibit a significant increase in skin tumors. The mice received 20 mg kg-1 DMDNB divided into six intragastric doses over 2 weeks and were promoted three times per week for 20 weeks.
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Authors | T V Reddy, G R Olson, F B Daniel, M Robinson |
Journal | Journal of applied toxicology : JAT
(J Appl Toxicol)
1994 May-Jun
Vol. 14
Issue 3
Pg. 231-2
ISSN: 0260-437X [Print] England |
PMID | 8083485
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Butanes
- Carcinogens
- 2,3-dimethyl-2,3-dinitrobutane
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Topics |
- Animals
- Butanes
(toxicity)
- Carcinogenicity Tests
(methods)
- Carcinogens
(toxicity)
- Female
- Mice
- Mice, Inbred Strains
- Skin Neoplasms
(chemically induced)
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