Abstract | BACKGROUND: Preactivation is a novel photochemical method for the production of chemotherapeutic compounds that exert their biologic effects independent of light. The compounds that are produced, preactivated merocyanine 540 (pMC540) and merodantoin, are cytotoxic to cultured human breast cancer cells but are only minimally cytotoxic toward normal cells. Their effects against breast cancer have not been studied in vivo. METHODS: RESULTS: Direct injection of established tumors with eight doses of pMC540 (250 mg/kg) administered on alternate days resulted in significant tumor regression (P = 0.002). In three of seven animals, palpable tumors could not be detected after this treatment (16 days). Treatment through intramuscular injections (20 doses) with pMC540 (250 mg/kg) also caused a significant suppression of tumor area (P = 0.004; P = 0.0882; P = 0.0903) and a marginally significant suppression of tumor weight and volume, respectively. Combined treatment with tamoxifen and pMC540 (100 mg/kg) caused a 67% suppression of breast tumor growth. Treatment with 20 doses of merodantoin (75 mg/kg) suppressed the growth of breast tumors by 98%. CONCLUSION: To the authors' knowledge, these results show for the first time that photochemically generated novel compounds in pMC540 alone and in combination with tamoxifen are effective in suppressing in vivo growth of xenografted human MCF-7 breast tumors.
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Authors | K S Gulliya, R K Sharma, J L Matthews, A C Benniston, A Harriman, J J Nemunaitis |
Journal | Cancer
(Cancer)
Vol. 74
Issue 6
Pg. 1725-32
(Sep 15 1994)
ISSN: 0008-543X [Print] United States |
PMID | 8082074
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Pyrimidinones
- Tamoxifen
- merodantoin
- Ethylenethiourea
- merocyanine dye
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Topics |
- Animals
- Breast Neoplasms
(drug therapy, pathology)
- Cell Division
(drug effects)
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Ethylenethiourea
(analogs & derivatives, pharmacology)
- Humans
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasms, Hormone-Dependent
(drug therapy, pathology)
- Pyrimidinones
(pharmacology)
- Tamoxifen
(pharmacology)
- Transplantation, Heterologous
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