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Antithrombotic activity of clove oil.

Abstract
Clove oil inhibited human platelet aggregation induced by arachidonic acid (AA), platelet-activating factor (PAF) or collagen. Clove oil was a more effective inhibitor for aggregation induced by AA and PAF (IC50:4 and 6 microM respectively) than collagen (IC50: 132 microM). The in vivo experiments in rabbits showed that clove oil (50-100 mg/kg) afforded 100% protection against PAF (11 mg/kg, i.v.) and 70% protection against AA (2.0 mg/kg, i.v.)-induced thrombosis and shock due to pulmonary platelet thrombosis. It also inhibited thromboxane-A2 and 12-HETE production by human platelets incubated with [C14] AA. These results are indicative that clove oil is inhibitory of platelet aggregation and thromboxane synthesis and may act as anti-thrombotic agent.
AuthorsS A Saeed, A H Gilani
JournalJPMA. The Journal of the Pakistan Medical Association (J Pak Med Assoc) Vol. 44 Issue 5 Pg. 112-5 (May 1994) ISSN: 0030-9982 [Print] Pakistan
PMID8078176 (Publication Type: Journal Article)
Chemical References
  • Arachidonic Acids
  • Platelet Activating Factor
  • Platelet Aggregation Inhibitors
  • Eugenol
Topics
  • Animals
  • Arachidonic Acids (antagonists & inhibitors)
  • Blood Platelets (metabolism)
  • Eugenol (pharmacology)
  • Male
  • Platelet Activating Factor (antagonists & inhibitors)
  • Platelet Aggregation Inhibitors (pharmacology)
  • Pulmonary Embolism (chemically induced, drug therapy)
  • Rabbits
  • Rats
  • Rats, Sprague-Dawley
  • Thrombosis (chemically induced, drug therapy)

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