Abstract |
Clove oil inhibited human platelet aggregation induced by arachidonic acid (AA), platelet-activating factor (PAF) or collagen. Clove oil was a more effective inhibitor for aggregation induced by AA and PAF (IC50:4 and 6 microM respectively) than collagen (IC50: 132 microM). The in vivo experiments in rabbits showed that clove oil (50-100 mg/kg) afforded 100% protection against PAF (11 mg/kg, i.v.) and 70% protection against AA (2.0 mg/kg, i.v.)-induced thrombosis and shock due to pulmonary platelet thrombosis. It also inhibited thromboxane-A2 and 12-HETE production by human platelets incubated with [C14] AA. These results are indicative that clove oil is inhibitory of platelet aggregation and thromboxane synthesis and may act as anti-thrombotic agent.
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Authors | S A Saeed, A H Gilani |
Journal | JPMA. The Journal of the Pakistan Medical Association
(J Pak Med Assoc)
Vol. 44
Issue 5
Pg. 112-5
(May 1994)
ISSN: 0030-9982 [Print] Pakistan |
PMID | 8078176
(Publication Type: Journal Article)
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Chemical References |
- Arachidonic Acids
- Platelet Activating Factor
- Platelet Aggregation Inhibitors
- Eugenol
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Topics |
- Animals
- Arachidonic Acids
(antagonists & inhibitors)
- Blood Platelets
(metabolism)
- Eugenol
(pharmacology)
- Male
- Platelet Activating Factor
(antagonists & inhibitors)
- Platelet Aggregation Inhibitors
(pharmacology)
- Pulmonary Embolism
(chemically induced, drug therapy)
- Rabbits
- Rats
- Rats, Sprague-Dawley
- Thrombosis
(chemically induced, drug therapy)
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