Abstract | OBJECTIVE: DESIGN: Randomized, double blind and placebo controlled parallel study. SETTING: The out-patient clinic of the Department of Pulmonary Medicine, Gentofte Hospital, Copenhagen, Denmark. SUBJECTS: Twenty-one untreated patients (17 males, 4 females, median age 33 years, range 21-65) and eight patients treated with systemic prednisolone. All patients had biopsy proven pulmonary sarcoidosis radiological stage I-III. INTERVENTIONS: Treatment with either inhaled budesonide 1.2 mg day-1-2.0 mg day-1 (n = 9) or placebo (n = 12) for 12 months. MAIN OUTCOME MEASURES: Clinical ( cough, chest pain, dyspnoea) and paraclinical variables (chest X-ray, gallium scintigraphy, pulmonary function tests, and biochemical markers of disease activity: blood leukocytes, lymphocytes, serum (S-) angiotensin converting enzyme (ACE), S-1,25- OH- cholecalciferol, plasma (P-) calcium, P- immunoglobulins) were recorded before treatment, every three months during treatment, and 6 months after treatment had been discontinued. RESULTS: There were no significant differences between the recorded variables in the budesonide and placebo groups. In general, a regression of disease activity was observed in both groups. Two patients in the treatment group, treated with 2.0 mg budesonide/day, and two in the placebo group had progression in disease and were put on systemic steroids. CONCLUSION:
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Authors | N Milman, N Graudal, G Grode, E Munch |
Journal | Journal of internal medicine
(J Intern Med)
Vol. 236
Issue 3
Pg. 285-90
(Sep 1994)
ISSN: 0954-6820 [Print] England |
PMID | 8077885
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aerosols
- Anti-Inflammatory Agents
- Bronchodilator Agents
- Glucocorticoids
- Pregnenediones
- Budesonide
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Topics |
- Administration, Inhalation
- Administration, Topical
- Adult
- Aerosols
- Analysis of Variance
- Anti-Inflammatory Agents
(administration & dosage, therapeutic use)
- Bronchodilator Agents
(administration & dosage, therapeutic use)
- Budesonide
- Double-Blind Method
- Female
- Glucocorticoids
- Humans
- Male
- Middle Aged
- Pregnenediones
(administration & dosage, therapeutic use)
- Radiography
- Respiratory Function Tests
- Sarcoidosis, Pulmonary
(diagnostic imaging, drug therapy, physiopathology)
- Treatment Failure
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