HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

No effect of high-dose inhaled steroids in pulmonary sarcoidosis: a double-blind, placebo-controlled study.

AbstractOBJECTIVE:
To evaluate whether inhaled steroids in high doses might be of therapeutic value in pulmonary sarcoidosis.
DESIGN:
Randomized, double blind and placebo controlled parallel study.
SETTING:
The out-patient clinic of the Department of Pulmonary Medicine, Gentofte Hospital, Copenhagen, Denmark.
SUBJECTS:
Twenty-one untreated patients (17 males, 4 females, median age 33 years, range 21-65) and eight patients treated with systemic prednisolone. All patients had biopsy proven pulmonary sarcoidosis radiological stage I-III.
INTERVENTIONS:
Treatment with either inhaled budesonide 1.2 mg day-1-2.0 mg day-1 (n = 9) or placebo (n = 12) for 12 months.
MAIN OUTCOME MEASURES:
Clinical (cough, chest pain, dyspnoea) and paraclinical variables (chest X-ray, gallium scintigraphy, pulmonary function tests, and biochemical markers of disease activity: blood leukocytes, lymphocytes, serum (S-) angiotensin converting enzyme (ACE), S-1,25-OH-cholecalciferol, plasma (P-) calcium, P-immunoglobulins) were recorded before treatment, every three months during treatment, and 6 months after treatment had been discontinued.
RESULTS:
There were no significant differences between the recorded variables in the budesonide and placebo groups. In general, a regression of disease activity was observed in both groups. Two patients in the treatment group, treated with 2.0 mg budesonide/day, and two in the placebo group had progression in disease and were put on systemic steroids.
CONCLUSION:
Inhaled budesonide in doses of 1.2-2.0 mg day-1 had no recognizable therapeutic effect on pulmonary sarcoidosis.
AuthorsN Milman, N Graudal, G Grode, E Munch
JournalJournal of internal medicine (J Intern Med) Vol. 236 Issue 3 Pg. 285-90 (Sep 1994) ISSN: 0954-6820 [Print] England
PMID8077885 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Aerosols
  • Anti-Inflammatory Agents
  • Bronchodilator Agents
  • Glucocorticoids
  • Pregnenediones
  • Budesonide
Topics
  • Administration, Inhalation
  • Administration, Topical
  • Adult
  • Aerosols
  • Analysis of Variance
  • Anti-Inflammatory Agents (administration & dosage, therapeutic use)
  • Bronchodilator Agents (administration & dosage, therapeutic use)
  • Budesonide
  • Double-Blind Method
  • Female
  • Glucocorticoids
  • Humans
  • Male
  • Middle Aged
  • Pregnenediones (administration & dosage, therapeutic use)
  • Radiography
  • Respiratory Function Tests
  • Sarcoidosis, Pulmonary (diagnostic imaging, drug therapy, physiopathology)
  • Treatment Failure

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: