Lysine clonixinate in minor dental surgery: double-blind randomized parallel study versus paracetamol.

Abstract

Lysine clonixinate (LC), an effective and well tolerated non-morphinic analgesic whose mechanism of action is basically due to the inhibition of cyclo-oxygenase, was assessed with a double-blind randomized dummy design versus paracetamol (P) on 200 patients suffering from pain after minor dental surgery. Patients received according to their needs 1 or 2 tablets of 125 mg lysine clonixinate or 500 mg paracetamol every 8 h during 48 h or until pain relief. Both groups, each composed of 100 patients, were comparable in terms of demographic conditions (t test), initial symptoms (chi-square test), characteristics of the extracted dental pieces, surgical complications and wound treatment (chi-square test). Pain intensity scores and daily average intake of tablets (3.4/day) documented in the patients' diary revealed no statistically significant differences between the two treatments (chi-square test). It was found that spontaneous pain measured using a visual analogue scale (VAS) decreased significantly in both treatment groups at the 24-h control examination. The following values were observed in the LC group: baseline 4.38 +/- 1.7; 24-h * 1.20 +/- 1.4; 48-h * 0.36 +/- 1.2. In the P group the values were: baseline 4.28 +/- 1.6; 24-h * 1.11 +/- 1.4; 48-h * 0.30 +/- 0.7 (*p < 0.05). Other variables like facial swelling and night pain, evaluated on a score from 0 to 4 and symptom presence or absence respectively, showed a similar response.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: M L Martí, A R De los Santos, G Di Girolamo, M Gil, E O Manero, C Fraga
• Journal: International journal of tissue reactions (Int J Tissue React) Vol. 15 Issue 5 Pg. 207-13 ( 1993) ISSN: 0250-0868 [Print] Switzerland
• PMID: 8077090 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics
• lysine clonixinate
• Acetaminophen
• Lysine
• Clonixin

Topics

• Acetaminophen (adverse effects, standards, therapeutic use)
• Adolescent
• Adult
• Aged
• Analgesics (adverse effects, standards, therapeutic use)
• Clonixin (adverse effects, analogs & derivatives, standards, therapeutic use)
• Double-Blind Method
• Female
• Humans
• Lysine (adverse effects, analogs & derivatives, standards, therapeutic use)
• Male
• Mathematics
• Middle Aged
• Pain (drug therapy)
• Pain Measurement
• Surgery, Oral (methods)
• Time Factors