Abstract |
Generalized bovine herpesvirus 1 (BHV-1) infection was diagnosed in six Salers calves from the same herd. The calves had received an intramuscular injection of modified-live infectious bovine rhinotracheitis parainfluenza-3 vaccine between birth and three days of age. The purpose of this study was to determine if the outbreak was associated with the vaccine strain of BHV-1. Analysis of epidemiological data and BHV-1 DNA for restriction fragment length polymorphism was undertaken. Multifocal necrosis in multiple organs was observed on pathological examination, and the presence of BHV-1 in tissues was confirmed by immunohistochemistry. Forty-three calves (aged birth to thirty days) were vaccinated over an 11-day interval. The 10 deaths recorded for vaccinated calves were clustered over a subsequent 14-day interval. Mortality in calves vaccinated between birth and three days of age was significantly higher than in nonvaccinated calves (chi-square test; p < or = 0.025), and this mortality was characterized by a greater age at death and duration of illness for vaccinated calves (t test; p < or = 0.001). The patterns of the restriction fragments, generated by six restriction endonucleases, of BHV-1 isolated from a necropsied calf and from the vaccine were identical, and different from that of a laboratory strain of BHV-1 (P8-2). These findings support the conclusion that newborn calves were susceptible to an intramuscularly injected vaccine strain of BHV-1, and that administration of an intramuscular modified-live infectious bovine rhinotracheitis parainfluenza-3 vaccine to neonatal calves may not be an innocuous procedure.
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Authors | L A Bryan, R A Fenton, V Misra, D M Haines |
Journal | The Canadian veterinary journal = La revue veterinaire canadienne
(Can Vet J)
Vol. 35
Issue 4
Pg. 223-8
(Apr 1994)
ISSN: 0008-5286 [Print] Canada |
PMID | 8076277
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Viral
- Vaccines, Attenuated
- Viral Vaccines
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Topics |
- Alberta
(epidemiology)
- Animals
- Animals, Newborn
- Antigens, Viral
(analysis)
- Cattle
- Cattle Diseases
(diagnosis, epidemiology, microbiology)
- Disease Outbreaks
(veterinary)
- Female
- Herpesviridae Infections
(diagnosis, epidemiology, microbiology, veterinary)
- Herpesvirus 1, Bovine
(isolation & purification)
- Parainfluenza Virus 3, Human
(immunology)
- Respiratory Tract Infections
(diagnosis, microbiology, veterinary)
- Vaccines, Attenuated
(adverse effects, immunology)
- Viral Vaccines
(adverse effects, immunology)
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