Potent anti-tumor activity and low toxicity of tubeimoside 1 isolated from Bolbostemma paniculatum.

Abstract

Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae) is a traditional Chinese medicinal plant (1), from which tubeimoside 1 was isolated. The antitumor activity and toxicity of tubeimoside 1 was investigated in vivo and in vitro. The results showed that tubeimoside 1 exerts potent anti-tumor activity with low toxicity. The compound inhibited DNA synthesis and induced phenotypic reverse transformation of tumor cells.

• Authors: L Yu, R Ma, Y Wang, H Nishino
• Journal: Planta medica (Planta Med) Vol. 60 Issue 3 Pg. 204-8 (Jun 1994) ISSN: 0032-0943 [Print] Germany
• PMID: 8073083 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Drugs, Chinese Herbal
• Saponins
• Triterpenes
• tubeimoside I

Topics

• Animals
• Antineoplastic Agents, Phytogenic (pharmacology, toxicity)
• Drugs, Chinese Herbal
• Female
• Humans
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Inbred ICR
• Saponins (pharmacology, toxicity)
• Triterpenes (pharmacology, toxicity)
• Tumor Cells, Cultured