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Impaired accumulation of a cationic photosensitizing agent by a cell line exhibiting multidrug resistance.

Abstract
Transport and accumulation of copper benzochlorin iminium salt (CDS1), a cationic photosensitizing agent, were examined using the P388/ADR murine leukemia, which exhibits the MDR (multidrug resistance) phenotype, and the wild-type parent cell line, P388. The recent availability of radioactive CDS1 permitted kinetic studies at drug levels in the submicromolar range. Exclusion of CDS1 by P388/ADR cells could be demonstrated, indicating that this agent is a substrate for the outward transport system associated with MDR. These results have implications with regard to the efficacy of cationic photosensitizers against this common neoplastic phenotype. The CDS1 was readily accumulated by P388 cells and by P388/ADR cells when the outward transport system was inhibited. Under these conditions, CDS1 was tightly bound and could not be washed out even when the outward transport system was reactivated.
AuthorsD Kessel, K Woodburn, D Skalkos
JournalPhotochemistry and photobiology (Photochem Photobiol) Vol. 60 Issue 1 Pg. 61-3 (Jul 1994) ISSN: 0031-8655 [Print] United States
PMID8073077 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Cations
  • Deuteroporphyrins
  • Imines
  • Photosensitizing Agents
  • copper benzochlorin
  • Daunorubicin
Topics
  • Animals
  • Cations
  • Daunorubicin (pharmacokinetics, pharmacology)
  • Deuteroporphyrins (pharmacokinetics)
  • Drug Resistance
  • Imines (pharmacokinetics)
  • Mice
  • Photosensitizing Agents (pharmacokinetics)
  • Tumor Cells, Cultured

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